by SmartTots | Mar 13, 2020 | Research Articles
Abstract Background: Some recent clinical studies have found that early childhood exposure to anesthesia is associated with increased risks of behavioral deficits and clinical diagnoses of attention deficit/hyperactivity disorder (ADHD). While diagnoses in claims data...
by SmartTots | Mar 13, 2020 | Research Articles
Abstract Nitrous oxide (N2O) is frequently used for short anesthesia/analgesia in children undergoing painful or repetitive procedures. Children with acute lymphoblastic leukemia (ALL) require repeated lumbar punctures with direct instillation of intrathecal...
by SmartTots | Mar 13, 2020 | Research Articles
Abstract One of the fundamental requirements of clinical research is a clear, a priori description of variables to be collected to answer the proposed research question. The process by which a concept or phenomenon will be measured is referred to as...
by SmartTots | Jan 14, 2020 | Research Articles
Abstract Ample evidence has surfaced documenting the neurotoxic effects of various general anesthetic (GA) agents in the mammalian brain when administered at critical periods of synaptogenesis. However, little is known about how this neurotoxic insult affects...
by SmartTots | Jan 14, 2020 | Research Articles
Abstract Sedatives and anesthetics can injure the developing brain. They cause apoptosis of neurons and oligodendrocytes, impair synaptic plasticity, inhibit neurogenesis and trigger long-term neurocognitive deficits. The projected vulnerable period in humans extends...
