by SmartTots | Jan 14, 2020 | Research Articles
Abstract Fifteen years ago Olney and colleagues began using animal models to evaluate the effects of anesthetic and sedative agents (ASAs) on neurodevelopment. The results from ongoing studies indicate that, under certain conditions, exposure to these drugs during...
by SmartTots | Jan 14, 2020 | Research Articles
Abstract Isoflurane anesthesia induces neuroapoptosis in the development of the brain. In this study, neonatal rats and hippocampal neurons were subjected to isoflurane exposure, in which the effect of miR‐124 on the neurological deficits induced by isoflurane was...
by SmartTots | Jan 14, 2020 | Research Articles
Abstract Aims Anaesthesia-related neurotoxicity in the developing brain is a controversial issue that has recently attracted much attention. Hemin plays a protective role in hypoxic and ischemic brain damage; however, its effects on sevoflurane-induced neurotoxicity...
by SmartTots | Jan 14, 2020 | Research Articles
Abstract Editor’s Perspective: What We Already Know about This Topic: Oligodendrocyte proliferation and maturation are prerequisites for myelination in the central nervous system. Disruption of these processes can lead to long-term impairment of neural function....
by SmartTots | Jan 14, 2020 | Research Articles
Abstract Background Recently, the US Food and Drug Administration called for cautious use of anesthetic drugs during pregnancy. In 0.2−2% of pregnancies, nonobstetric surgery is being performed. The consequences of anesthesia during pregnancy on fetal development...
