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Using animal models to evaluate the functional consequences of anesthesia during early neurodevelopment

by SmartTots | Jan 14, 2020 | Research Articles

Abstract Fifteen years ago Olney and colleagues began using animal models to evaluate the effects of anesthetic and sedative agents (ASAs) on neurodevelopment. The results from ongoing studies indicate that, under certain conditions, exposure to these drugs during...

microRNA‐124 attenuates isoflurane‐induced neurological deficits in neonatal rats via binding to EGR1

by SmartTots | Jan 14, 2020 | Research Articles

Abstract Isoflurane anesthesia induces neuroapoptosis in the development of the brain. In this study, neonatal rats and hippocampal neurons were subjected to isoflurane exposure, in which the effect of miR‐124 on the neurological deficits induced by isoflurane was...

Hemin treatment protects neonatal rats from sevoflurane-induced neurotoxicity via the phosphoinositide 3-kinase/Akt pathway

by SmartTots | Jan 14, 2020 | Research Articles

Abstract Aims Anaesthesia-related neurotoxicity in the developing brain is a controversial issue that has recently attracted much attention. Hemin plays a protective role in hypoxic and ischemic brain damage; however, its effects on sevoflurane-induced neurotoxicity...

Early Postnatal Exposure to Isoflurane Disrupts Oligodendrocyte Development and Myelin Formation in the Mouse Hippocampus

by SmartTots | Jan 14, 2020 | Research Articles

Abstract Editor’s Perspective: What We Already Know about This Topic: Oligodendrocyte proliferation and maturation are prerequisites for myelination in the central nervous system. Disruption of these processes can lead to long-term impairment of neural function....

Maternal surgery during pregnancy has a transient adverse effect on the developing fetal rabbit brain

by SmartTots | Jan 14, 2020 | Research Articles

Abstract Background Recently, the US Food and Drug Administration called for cautious use of anesthetic drugs during pregnancy. In 0.2−2% of pregnancies, nonobstetric surgery is being performed. The consequences of anesthesia during pregnancy on fetal development...
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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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