by SmartTots | Jan 14, 2020 | Research Articles
Abstract Ketamine is widely used in infants and young children for anesthesia, and subanesthetic doses of ketamine make neurons form new protrusions and promote synapse formation. However, the precise pathological mechanisms remain to be elucidated. In this study, we...
by SmartTots | Jan 14, 2020 | Research Articles
Abstract Background: The concept of anaesthesia-related neonatal neurotoxicity originated in neonatal rodent models, yet prospective clinical studies have largely not supported this concern. Objectives: To determine the frequency and magnitude of hypercarbia, hypoxia...
by SmartTots | Jan 14, 2020 | Research Articles
Abstract We aimed to evaluate the neurotoxicity and mechanisms of anesthetics propofol in hESC-derived neurons. Cell apoptosis in hESC-derived neurons’ exposure to 4, 10 and 20 μg/mL propofol for 6 h was assessed using terminal deoxynucleotidyl...
by SmartTots | Jan 14, 2020 | Research Articles
Abstract Children with repeated inhalational anesthesia may develop cognitive disorders. This study aimed to investigate the transcriptome-wide response of hippocampus in young mice that had been exposed to multiple sevoflurane in the neonatal period. Mice received 3%...
by SmartTots | Jan 14, 2020 | Research Articles
Abstract Isoflurane is a commonly used inhalational anesthetic that can induce neurotoxicity, while Dexmedetomidine (Dex) has significant neuroprotective effects. In our study, we explored the effects of Dex on isoflurane-induced neurotoxicity through the TLR2/NF-κB...
