by SmartTots | Jan 14, 2020 | Research Articles
Abstract Aim: Explore if dexmedetomidine (DEX) improves neurodevelopment and cognitive impairment in infants with congenital heart disease. Materials & Methods: We retrospectively analyzed 256 pediatric patients aged less than 2 years with heart disease undergoing...
by SmartTots | Nov 3, 2019 | Research Articles
Abstract Aims: It is well established that exposure of common anesthetic isoflurane in early life can induce neuronal apoptosis and long-lasting cognitive deficit, but the underlying mechanisms were not well understood. The cell cycle protein Cyclin B1 plays an...
by SmartTots | Nov 3, 2019 | Research Articles
Abstract Early life exposure to general anesthetics can have neurotoxic consequences. Evidence indicates that xenon, a rare noble gas with anesthetic properties, may lessen neuronal damage under certain conditions. However, its potential neuroprotective properties,...
by SmartTots | Nov 3, 2019 | Research Articles
Abstract Rationale: Animal studies have shown that early postnatal propofol administration is involved in neurobehavioral alterations in adults. However, the underlying mechanism is not clear. Methods: We used c-Fos immunohistochemistry to identify activated neurons...
by SmartTots | Nov 3, 2019 | Research Articles
Abstract Purpose: Evidence has shown that propofol may cause widespread apoptotic neurodegeneration. Hypoxic preconditioning has been demonstrated to provide neuroprotection and brain recovery from both acute and chronic neurodegeneration in several cellular and...
