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Neurotoxicity of Inhalation Anesthetics in the Neonatal Rat Brain: Effects on Behavior and Neurodegeneration in the Piriform Cortex.

by SmartTots | Jul 19, 2018 | Research Articles

Abstract There is concern that clinical use of anesthetic drugs may cause neurotoxicity in the developing brain and subsequent abnormal neurobehavior. We therefore evaluated neurotoxic effects of inhalation anesthetics in the neonatal rat brain, using in vivo...

Does pediatric anesthesia cause brain damage? Addressing parental and provider concerns in light of compelling animal studies and seemingly ambivalent human data.

by SmartTots | Jul 19, 2018 | Research Articles

Abstract Anesthesia facilitates surgery in millions of young children every year. Structural brain abnormalities and functional impairment observed in animals has created substantial concerns among clinicians, parents, and government regulators. Clinical studies...

The postoperative effect of sevoflurane inhalational anesthesia on cognitive function and inflammatory response of pediatric patients.

by SmartTots | Jul 19, 2018 | Research Articles

Abstract OBJECTIVE: To investigate the effect of sevoflurane on cognitive function and inflammatory response of children after general anesthesia at different times. PATIENTS AND METHODS: Ninety-three pediatric patients who underwent general anesthesia surgery were...

General anesthetics and cytotoxicity: possible implications for brain health.

by SmartTots | Jul 19, 2018 | Research Articles

Abstract BACKGROUND: The search for agents that bring about faster induction and quicker recovery in the operating room have yielded numerous anesthetics whose mechanisms of action and potential toxic side effects remain unknown, especially in the young and aging...

Update on developmental anesthesia neurotoxicity.

by SmartTots | Jul 19, 2018 | Research Articles

Abstract PURPOSE OF REVIEW: Adverse long-term impact of general anesthesia on the developing brain is a widely discussed and controversial issue with potential public health relevance. The goal of this article is to give insights into the most recent experimental and...
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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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