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Obstetricians balk at FDA warning on anesthesia in pregnant women

by SmartTots | Mar 19, 2017 | News, Research Articles

Repeated or lengthy use of general anesthetic and sedation drugs in infants, toddlers and pregnant women in their third trimester might damage children’s developing brains, the U.S. Food and Drug Administration warned this month. Upset that the warning about pregnant...

What parents should know about the use of general anesthesia in toddlers

by SmartTots | Mar 19, 2017 | News, Research Articles

Children’s hospitals across Canada are advising parents not to delay necessary surgeries out of fears raised by a U.S. Food and Drug Administration warning that repeated or lengthy exposure to general anesthesia may harm brain development in children under 3. The FDA...

FDA warns of anesthesia risk in pregnant women, kids under 3

by SmartTots | Mar 19, 2017 | News, Research Articles

Repeated or lengthy use — longer than three hours — of general anesthetic and sedation drugs may harm the developing brains of fetuses and children younger than 3 years old, the U.S. Food and Drug Administration warned Wednesday. After reviewing the latest published...

Anesthesia and Developing Brains—Implications of the FDA Warning

by SmartTots | Mar 18, 2017 | Research Articles

For more than 15 years, the potential for lasting neurotoxic effects of agents used to induce general anesthesia and sedation when administered to young children — and indirectly through pregnant women to fetuses with developing brains — has been a subject of concern...

Neonatal anesthetic neurotoxicity: Insight into the molecular mechanisms of long-term neurocognitive deficits

by SmartTots | Mar 18, 2017 | Research Articles

Abstract Mounting animal studies have demonstrated that almost all the clinically used general anesthetics could induce widespread neuroapoptosis in the immature brain. Alarmingly, some published findings have reported long-term neurocognitive deficits in response to...
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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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