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Risk of Neurotoxicity with Multiple General Anaesthetics for Examination Under Anaesthesia in Paediatric Ophthalmology – A Cause for Concern?

by SmartTots | Feb 14, 2023 | Clinical Articles, Research Articles

Abstract Purpose: To evaluate the impact of clinical protocol change via active minimisation on the number of general anaesthetic (GA)/sedation episodes for diagnostic ophthalmic purposes at Children’s Health Ireland at Temple Street (CHI-TS), Dublin, Ireland,...

Opioids and autism spectrum disorder: liaisons dangereuses?

by SmartTots | Feb 14, 2023 | Clinical Articles, Research Articles

A recent laboratory study in the British Journal of Anaesthesia examined the effects of repeated exposures of neonatal mice to fentanyl on autism-like behaviour via opioid receptor-mediated DNA hypermethylation of the Grin2B gene, which encodes the GluN2B subunit of...

Comparer Pommes et Oranges: Perils of Translating Rodent Studies to Human Outcomes

by SmartTots | Jan 16, 2023 | Clinical Articles, Research Articles

This editorial critiques the study by Salaün et al as it attempts to translate findings on the effects of anesthesia in neonatal rodents to children. There are many problems with this comparison: 1) investigators have no access to past anesthesia records in human...

Neurotoxic Impact of Individual Anesthetic Agents on the Developing Brain.

by SmartTots | Jan 4, 2023 | Clinical Articles, Research Articles

Abstract Concerns about the safety of anesthetic agents in children arose after animal studies revealed disruptions in neurodevelopment after exposure to commonly used anesthetic drugs. These animal studies revealed that volatile inhalational agents, propofol,...

Anesthesia and developing brain: What have we learned from recent studies.

by SmartTots | Jan 4, 2023 | Clinical Articles, Research Articles

Abstract Anesthesia is unavoidable in surgical procedures. However, whether the general anesthetics are neurotoxic to immature brains remains undefined. Neurodevelopmental impairment induced by anesthesia has been a critical health issue and topic of concern. This...

Anesthesia and neurodevelopment after 20 years: where are we now and where to next?

by SmartTots | Jan 4, 2023 | Clinical Articles, Research Articles

This editorial discusses recent government warnings on anesthesia in pregnant women and young children, the latest findings from clinical trials, unanswered questions about anesthesia and its association to neurotoxicity, and new directions in pediatric anesthesia...
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Recent Posts

  • Editorial: Anesthetic neurotoxicity in developing brains: mechanisms, biomarkers, and therapeutic targets.
  • Development of a primate model to evaluate the effects of ketamine and surgical stress on the neonatal brain.
  • Sevoflurane anaesthesia induces cognitive impairment in young mice through sequential tau phosphorylation.
  • Dexmedetomidine suppresses hippocampal astrocyte pyroptosis in cerebral hypoxic-ischemic neonatal rats by upregulating microRNA-148a-3p to inactivate the STAT/JMJD3 axis.
  • miR-34a targets SIRT1 to reduce p53 deacetylation and promote sevoflurane inhalation anesthesia-induced neuronal autophagy and apoptosis in neonatal mice.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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