by SmartTots | Feb 14, 2023 | Clinical Articles, Research Articles
Abstract Children undergoing general anesthesia and surgery in the early years of life are exposed to the possible neurotoxicity of anesthetic agents. Prospective studies have shown deficits in behavior, executive function, social communication, and motor function in...
by SmartTots | Feb 14, 2023 | Clinical Articles, Research Articles
Abstract Purpose: To evaluate the impact of clinical protocol change via active minimisation on the number of general anaesthetic (GA)/sedation episodes for diagnostic ophthalmic purposes at Children’s Health Ireland at Temple Street (CHI-TS), Dublin, Ireland,...
by SmartTots | Feb 14, 2023 | Clinical Articles, Research Articles
A recent laboratory study in the British Journal of Anaesthesia examined the effects of repeated exposures of neonatal mice to fentanyl on autism-like behaviour via opioid receptor-mediated DNA hypermethylation of the Grin2B gene, which encodes the GluN2B subunit of...
by SmartTots | Jan 16, 2023 | Clinical Articles, Research Articles
This editorial critiques the study by Salaün et al as it attempts to translate findings on the effects of anesthesia in neonatal rodents to children. There are many problems with this comparison: 1) investigators have no access to past anesthesia records in human...
by SmartTots | Jan 4, 2023 | Clinical Articles, Research Articles
Abstract Concerns about the safety of anesthetic agents in children arose after animal studies revealed disruptions in neurodevelopment after exposure to commonly used anesthetic drugs. These animal studies revealed that volatile inhalational agents, propofol,...
by SmartTots | Jan 4, 2023 | Clinical Articles, Research Articles
Abstract Anesthesia is unavoidable in surgical procedures. However, whether the general anesthetics are neurotoxic to immature brains remains undefined. Neurodevelopmental impairment induced by anesthesia has been a critical health issue and topic of concern. This...
