by SmartTots | Jan 4, 2023 | Clinical Articles, Research Articles
Abstract BACKGROUND: One in 7 children will need general anesthesia (GA) before the age of 3. Brain toxicity of anesthetics is controversial. Our objective was to clarify whether exposure of GA to the developing brain could lead to lasting behavioral and structural...
by SmartTots | Jan 4, 2023 | Clinical Articles, Research Articles
Abstract Introduction: Dexmedetomidine is the sedative agent administered in combination with remifentanil and low dose of sevoflurane in the interventional arm of the ongoing TREX trial (Trial Remifentanil DExmedetomidine). The TREX pilot study (published in Paediatr...
by SmartTots | Nov 2, 2022 | Clinical Articles, Research Articles
Abstract Background: Electroencephalogram (EEG) discontinuity can occur at high concentrations of anesthetic drugs, reflecting suppression of electrocortical activity. This EEG pattern has been reported in children and reflects a deep state of anesthesia. Isoelectric...
by SmartTots | Nov 2, 2022 | Clinical Articles, Research Articles
Abstract Background: Infants with prenatal opioid and substance exposure are at higher risk of poor neurobehavioral outcomes in later childhood. Early brain imaging in infancy has the potential to identify early brain developmental alterations that may help predict...
by SmartTots | Nov 2, 2022 | Clinical Articles, Research Articles
Abstract Background: Millions of children experienced surgery procedures requiring general anesthesia (GA). Any potential neurodevelopmental risks of pediatric anesthesia can be a serious public health issue. Various animal studies have provided evidence that commonly...
by SmartTots | Nov 2, 2022 | Clinical Articles, Research Articles
Abstract Background: Some studies have found surgery and anesthesia in children to be associated with neurodevelopmental deficits, but specific reasons for this association have not been fully explored. This study evaluates intraoperative mean arterial pressure (MAP)...
