by SmartTots | Feb 14, 2023 | Preclinical Articles, Research Articles
Abstract The use of fentanyl during pregnancy, whether by prescription or illicit use, may result in high blood levels that pose an early risk to fetal development. However, little is known regarding the neurotoxicity that might arise from excessive fentanyl exposure...
by SmartTots | Feb 14, 2023 | Preclinical Articles, Research Articles
Abstract Children repeatedly exposed to anaesthesia have a high risk of cognitive impairment, but the mechanism of its regulation in this context is unknown. The objective of this study was to investigate the possible toxic mechanism of sevoflurane through...
by SmartTots | Feb 14, 2023 | Preclinical Articles, Research Articles
Abstract Background: Multiple neonatal exposures to sevoflurane induce neurocognitive dysfunctions in rodents. The lack of cell-type specific information following sevoflurane exposure limits the mechanistic understanding of these effects. In this study, we tested the...
by SmartTots | Feb 14, 2023 | Preclinical Articles, Research Articles
Abstract The growth cone guides the axon or dendrite of striatal GABAergic projection neurons that protrude into the midbrain and cortex and form complex neuronal circuits and synaptic networks in a developing brain, aberrant projections and synaptic connections in...
by SmartTots | Feb 14, 2023 | Preclinical Articles, Research Articles
Abstract Developmental sevoflurane exposure leads to neuronal cell death, and subsequent learning and memory cognitive defects. The underlyi\ng mechanism remains to be elucidated. Gasdermin D (GSDMD)-mediated pyroptosis is a form of inflammatory cell death and...
by SmartTots | Feb 14, 2023 | Preclinical Articles, Research Articles
Abstract Sevoflurane is the primary inhaled anesthetic used in pediatric surgery. It has been the focus of research since animal models studies found that it was neurotoxic to the developing brain two decades ago. However, whether pediatric general anesthesia can lead...
