by SmartTots | Jan 4, 2023 | Preclinical Articles, Research Articles
Abstract Sevoflurane is a widely used general anaesthetic in paediatric patients. Although repeated sevoflurane exposure is known to cause neurodevelopmental disorders in children, the mechanism of this neurotoxicity remains largely unknown. Herein, we investigated...
by SmartTots | Jan 4, 2023 | Preclinical Articles, Research Articles
Abstract Background Propofol is a commonly used general anesthetic that may cause neuronal damage, especially in infants and young children. Mitochondria play an essential role in cellular metabolism and signal transduction. Propofol may cause neurotoxicity by...
by SmartTots | Jan 4, 2023 | Preclinical Articles, Research Articles
Abstract Ketamine, a popular anesthetic, is often abused by people for its hallucinogenic effect. Thus, the safety of ketamine in pediatric populations has been called into question for potential neurotoxic effects. However, ketamine also has neuroprotective effects...
by SmartTots | Jan 4, 2023 | Preclinical Articles, Research Articles
Abstract Sevoflurane anesthesia is reported to repress neurogenesis of neural stem cells (NSCs), thereby affecting the brain development, but the underlying mechanism of sevoflurane on the proliferation of NSCs remains unclear. Thus, this study aims to discern the...
by SmartTots | Jan 4, 2023 | Preclinical Articles, Research Articles
Abstract Repeated or prolonged early life exposure to anesthesia is neurotoxic in animals and associated with neurocognitive impairment in later life in humans. We used electron microscopy with unbiased stereological sampling to assess synaptic ultrastructure in...
by SmartTots | Jan 4, 2023 | Preclinical Articles, Research Articles
Abstract Sevoflurane inhalation is prone to initiate cognitive deficits in infants. The early growth response-2 (Egr-2) gene is DNA-binding transcription factor, involving in cognitive function. In this study we explored the molecular mechanisms underlying the...
