by SmartTots | Jan 4, 2023 | Preclinical Articles, Research Articles
Abstract Repeated or prolonged, but not short-term, general anesthesia during the early postnatal period causes long-lasting impairments in memory formation in various species. The mechanisms underlying long-lasting impairment in cognitive function are poorly...
by SmartTots | Jan 4, 2023 | Preclinical Articles, Research Articles
Abstract General anesthetics-induced neurotoxicity and cognitive impairment in developing brains have become one of the current research hotspots in the medical science community. The underlying mechanisms are complex and involve various related molecular signaling...
by SmartTots | Jan 4, 2023 | Preclinical Articles, Research Articles
Abstract Preclinical models demonstrate that nearly all anesthetics cause widespread neuroapoptosis in the developing brains of infant rodents and non-human primates. Anesthesia-induced developmental apoptosis is succeeded by prolonged neuropathology in the surviving...
by SmartTots | Jan 4, 2023 | Preclinical Articles, Research Articles
Abstract The general anesthesia associated with long-term cognitive impairment has been causing the concern of the whole society. In particular, repeated anesthetic exposures may affect executive function, processing speed, and fine motor skills, which all directly...
by SmartTots | Jan 4, 2023 | Preclinical Articles, Research Articles
Abstract Neonatal exposure to general anesthetics has been associated with neurotoxicity and morphologic changes in the developing brain. Isoflurane is a volatile anesthetic widely used in pediatric patients to induce general anesthesia, analgesia, and perioperative...
by SmartTots | Jan 4, 2023 | Preclinical Articles, Research Articles
Abstract Clinical trials and animal studies have indicated that long-term use or multiple administrations of anesthesia may lead to fine motor impairment in the developing brain. Most studies on anesthesia-induced neurotoxicity have focused on the hippocampus and...
