by SmartTots | Nov 2, 2022 | Preclinical Articles, Research Articles
Abstract The use of opioids during pregnancy has recently dramatically increased presenting major health problems, especially on the developing neonatal nervous system development. Nalufin is considered one of the most used opioid analgesics for treatment of moderate...
by SmartTots | Nov 2, 2022 | Preclinical Articles, Research Articles
Abstract Recent studies suggested that propofol, one of the most widely used anesthetics, may cause neurotoxicity in the developing brain, leading to cognitive deficits in adults. However, the underlying mechanisms remain unclear. In this study, we aimed to evaluate...
by SmartTots | Nov 2, 2022 | Preclinical Articles, Research Articles
Abstract Background: Developing brain is highly plastic and can be easily affected. Growing pediatric usage of anesthetics during painless procedures has raised concerns about the effect of low-dose anesthetics on neurodevelopment. It is urgent to ascertain the...
by SmartTots | Nov 2, 2022 | Preclinical Articles, Research Articles
Abstract Background: Ketamine, a non-competitive N-methyl-D-aspartate receptor (NMDAR) antagonist, is widely applicable to anesthesia, analgesia, and sedation. However, the function and mechanisms of ketamine in the long-term learning and memory function of neonatal...
by SmartTots | Nov 2, 2022 | Preclinical Articles, Research Articles
Abstract Use of the inhalation anesthetic isoflurane may increase the risk of cognitive deficiency and neurotoxicity after birth. A growing body of evidence suggests that melatonin is an effective treatment for various types of oxidative stress damage and...
by SmartTots | Nov 2, 2022 | Preclinical Articles, Research Articles
Abstract The profound programming effects of early life stress (ELS) on brain and behavior are thought to be primarily mediated by adrenal glucocorticoids (GCs). However, in mice, stressors are often administered between postnatal days 2 and 12 (PND2-12), during the...
