by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract The early developing brain is especially vulnerable to anesthesia, which can result in long lasting functional changes. We examined the effects of early-life propofol on adult excitatory-inhibitory balance and behavior. Postnatal day 7 male mice were exposed...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Zebrafish is known for its widespread neurogenesis and regenerative capacity, as well as several biological advantages, which turned it into a relevant animal model in several areas of research, namely in toxicological studies. Ketamine is a well-known...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract General anaesthetics (GA) have been in continuous clinical use for more than 170 years, with millions of young and elderly populations exposed to GA to relieve perioperative discomfort and carry out invasive examinations. Preclinical studies have shown that...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Objective: Dexmedetomidine use decreases adverse neurocognitive outcomes in adults undergoing cardiovascular surgery, but its effect has been unclear in children with congenital heart disease. Methods: The authors conducted a systematic review using the...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Surgery and anesthesia in neonates may lead to cognitive impairment or abnormal behaviors. It has been shown that autophagy plays a critical role in neuropsychiatric disorders, while the role of autophagy in postoperative cognitive impairment in neonates is...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Neurologic morbidity is highly prevalent in pediatric critical illness, and the use of benzodiazepines and/or opioids is a risk factor for delirium and post-discharge sequelae. However, little is known about how multidrug sedation with these medications...
