by SmartTots | May 1, 2023 | Preclinical Articles, Research Articles
Abstract Sevoflurane (Sevo) is one of the most commonly used general anesthetics for infants and young children. We investigated whether Sevo impairs neurological functions, myelination, and cognition via the γ-aminobutyric acid A receptor (GABAAR) and...
by SmartTots | May 1, 2023 | Preclinical Articles, Research Articles
Abstract Background: The anesthetic isoflurane can cause neurotoxicity in fetuses and offspring of rats, affecting their neurodevelopment. However, the underlying mechanisms and therapeutic targets of isoflurane-induced neurotoxicity remain to be identified....
by SmartTots | May 1, 2023 | Preclinical Articles, Research Articles
Abstract Background: Prolonged exposure to general anesthetics during development is known to cause neurobehavioral abnormalities, but the cellular and molecular mechanisms involved are unclear. Microglia are the resident immune cells in the central nervous system and...
by SmartTots | May 1, 2023 | Preclinical Articles, Research Articles
Abstract With the advancement of technology, increasingly many newborns are receiving general anesthesia at a young age for surgery, other interventions, or clinical assessment. Anesthetics cause neurotoxicity and apoptosis of nerve cells, leading to memory and...
by SmartTots | May 1, 2023 | Preclinical Articles, Research Articles
Abstract Propofol is the most commonly used intravenous general anesthetic in clinical anesthesia, and it is also widely used in general anesthesia for pregnant women and infants. Some clinical and preclinical studies have found that propofol causes damage to the...
by SmartTots | Feb 14, 2023 | Preclinical Articles, Research Articles
Abstract Developmental sevoflurane exposure leads to widespread neuronal cell death known as sevoflurane-induced neurotoxicity (SIN). Receptor-interacting protein kinase-3 (RIPK3) and mixed lineage kinase domain-like (MLKL)-driven necroptosis plays an important role...
