by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Ketamine, a noncompetitive N-methyl D-aspartate (NMDA) receptor antagonist, is widely used in pediatric clinical practice. The neuroprotective and neurotoxic effects of ketamine on brain neurons during development remain controversial. The reason may be...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Aims: Mid-gestational sevoflurane exposure may induce notable long-term neurocognitive impairment in offspring. This study was designed to investigate the role and potential mechanism of ferroptosis in developmental neurotoxicity induced by sevoflurane in the...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract General anesthetics are potent neurotoxins when given during early development, causing apoptotic deletion of substantial number of neurons and persistent neurocognitive and behavioral deficits in animals and humans. The period of intense synaptogenesis...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract There is increasing concern about the potential effects of anesthesia exposure on the developing brain. The effects of relatively brief anesthesia exposures used repeatedly to acquire serial magnetic resonance imaging scans could be examined prospectively in...
by SmartTots | Jun 28, 2023 | Clinical Articles, Research Articles
Abstract Pre-clinical experimental evidence, along with a plausible biological rational suggests that exposure of neonates and young children to anesthesia may harm brain development. However, the translational relevance of these observations remains unsolved. While a...
by SmartTots | Jun 28, 2023 | Clinical Articles, Research Articles
Abstract Over the past 20 years, hundreds of preclinical studies of the developing central nervous system have been published concluding that the common γ-aminobutryic acid and N-methyl-d-aspartate binding anesthetic agents cause neuroapoptosis and other forms of...
