by SmartTots | Jan 4, 2023 | Clinical Articles, Research Articles
Abstract BACKGROUND: One in 7 children will need general anesthesia (GA) before the age of 3. Brain toxicity of anesthetics is controversial. Our objective was to clarify whether exposure of GA to the developing brain could lead to lasting behavioral and structural...
by SmartTots | Jan 4, 2023 | Clinical Articles, Research Articles
Abstract Introduction: Dexmedetomidine is the sedative agent administered in combination with remifentanil and low dose of sevoflurane in the interventional arm of the ongoing TREX trial (Trial Remifentanil DExmedetomidine). The TREX pilot study (published in Paediatr...
by SmartTots | Nov 2, 2022 | Preclinical Articles, Research Articles
Abstract The use of opioids during pregnancy has recently dramatically increased presenting major health problems, especially on the developing neonatal nervous system development. Nalufin is considered one of the most used opioid analgesics for treatment of moderate...
by SmartTots | Nov 2, 2022 | Preclinical Articles, Research Articles
Abstract Recent studies suggested that propofol, one of the most widely used anesthetics, may cause neurotoxicity in the developing brain, leading to cognitive deficits in adults. However, the underlying mechanisms remain unclear. In this study, we aimed to evaluate...
by SmartTots | Nov 2, 2022 | Preclinical Articles, Research Articles
Abstract Background: Developing brain is highly plastic and can be easily affected. Growing pediatric usage of anesthetics during painless procedures has raised concerns about the effect of low-dose anesthetics on neurodevelopment. It is urgent to ascertain the...
by SmartTots | Nov 2, 2022 | Preclinical Articles, Research Articles
Abstract Background: Ketamine, a non-competitive N-methyl-D-aspartate receptor (NMDAR) antagonist, is widely applicable to anesthesia, analgesia, and sedation. However, the function and mechanisms of ketamine in the long-term learning and memory function of neonatal...
