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Global Brain Functional Network Connectivity in Infants With Prenatal Opioid Exposure.

by SmartTots | Nov 2, 2022 | Clinical Articles, Research Articles

Abstract Background: Infants with prenatal opioid and substance exposure are at higher risk of poor neurobehavioral outcomes in later childhood. Early brain imaging in infancy has the potential to identify early brain developmental alterations that may help predict...

General anesthesia in children and long-term neurodevelopmental deficits: A systematic review.

by SmartTots | Nov 2, 2022 | Clinical Articles, Research Articles

Abstract Background: Millions of children experienced surgery procedures requiring general anesthesia (GA). Any potential neurodevelopmental risks of pediatric anesthesia can be a serious public health issue. Various animal studies have provided evidence that commonly...

Intraoperative Blood Pressure and Long-Term Neurodevelopmental Function in Children Undergoing Ambulatory Surgery.

by SmartTots | Nov 2, 2022 | Clinical Articles, Research Articles

Abstract Background: Some studies have found surgery and anesthesia in children to be associated with neurodevelopmental deficits, but specific reasons for this association have not been fully explored. This study evaluates intraoperative mean arterial pressure (MAP)...

Neurodevelopmental outcomes after prenatal exposure to anaesthesia for maternal surgery: a propensity-score weighted bidirectional cohort study.

by SmartTots | Nov 2, 2022 | Clinical Articles, Research Articles

Abstract Up to 1% of pregnant women undergo anaesthesia for non-obstetric surgery. This study investigated neurodevelopmental outcomes after prenatal anaesthesia for maternal surgery. A bidirectional cohort study of children born between 2001 and 2018 was performed:...

General anesthesia in early childhood and possible association with autism: a population-based matched cohort study.

by SmartTots | Nov 2, 2022 | Clinical Articles, Research Articles

Abstract Background: In experimental animal studies, exposure to general anesthesia in early childhood may results in changes in infant brain morphology and behavior, potentially leading to the development of autistic behaviors in the long-term. However, in clinical...

Maternal use of acetaminophen during pregnancy and neurobehavioral problems in offspring at 3 years: A prospective cohort study

by SmartTots | Oct 12, 2022 | Clinical Articles, Research Articles

Abstract Background Acetaminophen is one of the most commonly used drugs during pregnancy globally. Recent studies have reported associations between prenatal exposure to acetaminophen and neurobehavioral problems in children, including attention-deficit hyperactivity...
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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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