by SmartTots | Aug 31, 2022 | Research Articles
Abstract Experimental studies have demonstrated that general anesthetics administered during the period of synaptogenesis may induce widespread neurodegeneration, which results in permanent cognitive and behavioral deficits. What remains to be elucidated is the extent...
by SmartTots | Aug 31, 2022 | Research Articles
Abstract Background: Sevoflurane exposure at brain developmental stages has been reported to induce neurotoxicity and, subsequently, results in learning deficits at the juvenile age. In this study, we aimed to investigate the effects of prior early-age sevoflurane...
by SmartTots | Aug 31, 2022 | Research Articles
Abstract Background: Environmental factors contribute to autism spectrum disorder. Fentanyl, one of the most widely used opioid analgesics in anaesthesia, can induce neurotoxicity, but its role in autism remains unknown. We determined whether fentanyl induced...
by SmartTots | Aug 31, 2022 | Research Articles
Abstract Background: The aim of the study was to determine the effects of repeated anesthesia exposure across postnatal development. Methods: Seventy-two newborn Sprague-Dawley rats were randomly divided into Sev group and Con-aged group. Sev groups were exposed to...
by SmartTots | Aug 31, 2022 | Research Articles
Abstract Multiple sevoflurane exposure may result in cognitive deficits in neonatal animals. This study attempted to investigate the potential mechanism of sevoflurane-induced neurotoxicity in developing hippocampus. Neonatal animals received sevoflurane anesthesia,...
by SmartTots | Aug 31, 2022 | Research Articles
Abstract Isoflurane (ISO) is a type of anesthetic that might cause neurotoxicity in children. Although miR-424-5p is considerably downregulated in ISO-treated rat brain samples, its physiological role in ISO-induced neuronal injury in human embryonic stem cell-derived...
