by SmartTots | Aug 31, 2022 | Research Articles
Abstract Emerging evidence from human epidemiologic and animal studies has demonstrated that developmental anesthesia neurotoxicity could cause long-term cognitive deficits and behavioral problems. However, the underlying mechanisms remain largely unknown. We...
by SmartTots | Aug 31, 2022 | Research Articles
Abstract Background: Anesthesia induces Tau phosphorylation and cognitive impairment in young, but not adult, mice. Apolipoprotein E (ApoE) may play a protective role in neuronal activity and injury repair, whereas its toxic fragments are reported to induce...
by SmartTots | Aug 31, 2022 | Research Articles
Abstract Barbiturates and benzodiazepines are GABAA-receptor agonists and potent antiseizure medications. We reported that exposure of neonatal macaques to combination of phenobarbital and midazolam (Pb/M) for 24 h, at clinically relevant doses and plasma levels,...
by SmartTots | Aug 31, 2022 | Research Articles
Abstract Rationale: Fetal exposure to general anesthesia may cause noteworthy neurocognitive impairment, but the mechanisms are unclear. Objectives: Our study designed to explore the potential mechanism of neurotoxicity in offspring rats after sevoflurane exposure to...
by SmartTots | Aug 31, 2022 | Research Articles
Abstract Background: Anesthesia and psychotropic drugs in pregnant women may cause long-term effects on the brain development of unborn babies. The authors set out to investigate the neurotoxicity of S-ketamine, which possesses anesthetic and antidepressant effects...
by SmartTots | Aug 31, 2022 | Research Articles
In this correspondence, the authors comment on the report by Shi and colleagues1 on the association between attention-deficit/hyperactivity disorder (ADHD) and exposure to anaesthesia in early childhood. The debate concerning the clinically relevant neurotoxic effects...
