by SmartTots | Aug 31, 2022 | Research Articles
Abstract Every year millions of children are exposed to general anesthesia while undergoing surgical and diagnostic procedures126,33,65. In the field of ophthalmology, 44,000 children are exposed to general anesthesia annually for strabismus surgery alone39. While it...
by SmartTots | Jul 7, 2022 | Research Articles
Abstract Background: Sevoflurane, a volatile anesthetic, is known to induce widespread neuronal degeneration and apoptosis. Recently, the stress-inducible protein sestrin 2 and adenosine monophosphate-activated protein kinase (AMPK) have been found to regulate the...
by SmartTots | Jul 7, 2022 | Research Articles
Abstract Objective: Neonatal exposure to propofol has been reported to cause neurotoxicity and neurocognitive decline in adulthood; however, the underlying mechanism has not been established. Methods: SD rats were exposed to propofol on postnatal day 7 (PND-7)....
by SmartTots | Jul 7, 2022 | Research Articles
Abstract It has been widely demonstrated by numerous preclinical studies and clinical trials that the neonates receiving repeated or long-time general anesthesia (GA) could develop prolonged cognitive dysfunction. However, the definite mechanism remains largely...
by SmartTots | Jul 7, 2022 | Research Articles
Abstract Inhaled anesthetics are known to induce neurotoxicity in the developing brains of rodents, although the mechanisms are not well understood. The aim of this study was to elucidate the molecular mechanisms underlying anesthetics-induced neurodevelopmental...
by SmartTots | Jul 7, 2022 | Research Articles
Abstract Background: The underlying molecular mechanisms of the excitatory/inhibitory (E/I) imbalance induced by sevoflurane exposure to neonates remain poorly understood. This study aimed to investigate the long-term effects of prolonged sevoflurane exposure to...
