by SmartTots | Jul 7, 2022 | Research Articles
Abstract Developmental neurotoxicity is a serious consequence of repeated exposure to sevoflurane during the postnatal period. Neuroinflammation is closely related to sevoflurane-induced developmental neurotoxicity. The present study explored the potential effect of...
by SmartTots | Jul 7, 2022 | Research Articles
Abstract Objective: Millions of children are exposed to anaesthetic drugs every day; however, the possible adverse effects of these agents on the central nervous system remain controversial. This study evaluated anaesthesiologists’ and pediatric surgeons’...
by SmartTots | Jul 7, 2022 | Research Articles
Abstract Background: The effects of sevoflurane anesthesia on childhood neurodevelopment and adult brain function have attracted increasing scientific attentions. However, the exact mechanisms underlying hyperphosphorylation of tau protein in sevoflurane induced...
by SmartTots | Jul 7, 2022 | Research Articles
Abstract Apoptosis, classically initiated by caspase pathway activation, plays a prominent role during normal brain development as well as in neurodegeneration. The noncanonical, nonlethal arm of the caspase pathway is evolutionarily conserved and has also been...
by SmartTots | Jul 7, 2022 | Research Articles
Abstract Objective: Sevoflurane is a common anesthetic and is widely used in pediatric clinical surgery to induce and maintain anesthesia through inhalation. Increasing studies have revealed that sevoflurane has neurotoxic effects on neurons, apoptosis, and memory...
by SmartTots | Jul 7, 2022 | Research Articles
Abstract Background: General anaesthesia in the neonatal period has detrimental effects on the developing mammalian brain. The impact of underlying inflammation on anaesthesia-induced developmental neurotoxicity remains largely unknown. Methods: Postnatal day 7 (PND7)...
