by SmartTots | Apr 28, 2022 | Research Articles
Abstract Objective: Prenatal sevoflurane exposure may pose neurotoxicity to embryonic brain development and lead to cognitive dysfunction in offspring, but the underlying mechanism is still unclear. We aimed to investigate whether sevoflurane could cause neurogenesis...
by SmartTots | Apr 28, 2022 | Research Articles
Abstract Neonatal anesthesia, while often essential for surgeries or imaging procedures, is accompanied by significant risks to redox balance in the brain due to the relatively weak antioxidant system in children. Oxidative stress is characterized by concentrations of...
by SmartTots | Apr 28, 2022 | Research Articles
Abstract Long non-coding RNA (lncRNA) small nucleolar RNA host gene 12 (SNHG12) has been reported to participate in the regulation of various nervous system disorders. Bupivacaine (BV), a commonly used local anesthetic, could generate neurotoxicity in neurons. This...
by SmartTots | Apr 28, 2022 | Research Articles
Abstract Propofol is one of the most common intravenous anesthetics which may cause neuronal cell death in young mice. HOX transcript antisense RNA (HOTAIR) was abnormally expressed in neurodegenerative diseases. However, the effect of HOTAIR on propofol-induced...
by SmartTots | Apr 28, 2022 | Research Articles
Abstract Aim: Ketamine is an anesthetic adjunct widely applied in the clinic that can induce hippocampal neurodegeneration in the brain. MicroRNAs (miRNAs) have been shown to be related to the regulation of ketamine-mediated neurotoxicity. This investigation aimed to...
by SmartTots | Apr 28, 2022 | Research Articles
Abstract Studies on rodents and nonhuman primates suggest that exposure to anesthetics, particularly in the young brain, is associated with neuronal apoptosis as well as hippocampal‑dependent cognitive dysfunction. Disruption of the development of dentate gyrus may...
