by SmartTots | Nov 16, 2021 | Research Articles
Abstract Objectives: To determine the characteristics of children who met the risk criteria for potential neurotoxicity defined by the US Food and Drug Administration (FDA; 2016 warning) in a procedural sedation (PS) service. Study design: A single-center...
by SmartTots | Nov 3, 2021 | Research Articles
Abstract Aim: Midazolam (MDZ) and thiopental are commonly used sedative agents. These two agents have been shown to have toxic apoptotic and neurodegenerative effects. The aim of this study was to investigate the effects of these drugs on neonatal and adult rat brain....
by SmartTots | Nov 3, 2021 | Research Articles
Abstract Background: Multiple studies have revealed that repeated or long-term exposure to ketamine causes neurodegeneration and cognitive dysfunction. Pyroptosis is an inflammatory form of programmed cell death that has been linked to various neurological diseases....
by SmartTots | Nov 3, 2021 | Research Articles
Abstract Background: Isoflurane, a widely used anesthetic in surgery, has been found to induce neurotoxicity. In parallel, genistein is thought to attenuate isoflurane-induced neurotoxicity, although underlying molecular mechanisms are still unclear. In this study, we...
by SmartTots | Nov 3, 2021 | Research Articles
Abstract Introduction: Recent animal studies showed that isoflurane exposure may lead to the disturbance of hippocampal neurogenesis and later cognitive impairment. However, much less is known about the effect of isoflurane exposure on the neurons generated form...
by SmartTots | Nov 2, 2021 | Research Articles
Abstract The mechanisms underlying propofol-induced toxicity in developing neurons are still unclear. The aim of present study was to explore the role of Pink1 mediated mitochondria pathway in propofol-induced developmental neurotoxicity. The primary Neural Stem Cells...
