by SmartTots | Nov 2, 2021 | Research Articles
Abstract This study tested the hypothesis that exposure of children prior to their third birthday to procedures requiring general anesthesia is associated with an increased incidence of autism spectrum disorder (ASD) in later life. This study employed a nested, 1:2...
by SmartTots | Nov 2, 2021 | Research Articles
The US Food and Drug Administration issued a warning in December 2016 that prolonged or repeated exposure to general anesthesia and sedatives that block N-methyl-D-aspartate (NMDA) receptors or potentiate gamma-aminobutyric acid (GABA) activity could have a...
by SmartTots | Oct 27, 2021 | Research Articles
Abstract In the midst of concerns for potential neurodevelopmental effects after surgical anesthesia, there is a growing awareness that children who require sedation during critical illness are susceptible to neurologic dysfunctions collectively termed pediatric...
by SmartTots | Sep 2, 2021 | Research Articles
Abstract Background Ketamine disrupts the proliferation and differentiation of developing neural stem cells (NSCs). Therefore, the safe use of ketamine in pediatric anesthesia has been an issue of increasing concern among anesthesiologists and children’s...
by SmartTots | Sep 1, 2021 | Research Articles
Abstract Propofol, a general intravenous anesthetic, has been demonstrated to cause a profound neuroapoptosis in the developing brain followed by long-term neurocognitive impairment. Our study aimed to examine the neuroprotective effect of neuronal PAS domain protein...
by SmartTots | Sep 1, 2021 | Research Articles
Abstract To investigate the effect of multiple propofol anesthesia and operative trauma on neuroinflammation and cognitive function in development rats and its mechanism. A total of 104 13-day-old neonatal Sprague-Dawley rats were randomly divided into 4 groups with...
