by SmartTots | Sep 1, 2023 | Preclinical Articles, Research Articles
Abstract Objective: Dexmedetomidine (DEX), a selective α2-adrenoceptor agonist, is an anesthetic and sedative agent and has been reported to confer neuroprotective effects after cerebral hypoxic ischemia (CHI). This study was undertaken to elucidate the mechanisms by...
by SmartTots | Sep 1, 2023 | Preclinical Articles, Research Articles
Abstract This study is to investigate the function of miR-34a and interactions between miR-34a, SIRT1, and p53 in sevoflurane-induced neuronal apoptosis and autophagy in neonatal mice. A mouse model was established by inhalation anesthesia with sevoflurane and...
by SmartTots | Sep 1, 2023 | Preclinical Articles, Research Articles
Abstract Propofol, a commonly used intravenous anesthetic, has been associated with neurodegeneration in the developing brain upon repeated exposure. Dexmedetomidine is an α2 adrenoceptor agonist that was previously reported to possess neuroprotective properties....
by SmartTots | Sep 1, 2023 | Preclinical Articles, Research Articles
Abstract Background: Developmental anesthetic neurotoxicity is well described in animal models for GABAergic, sedating drugs. Here we investigate the role of the benzodiazepine, diazepam on spatial and recognition memory of young adult rats after neonatal exposure....
by SmartTots | Sep 1, 2023 | Preclinical Articles, Research Articles
Abstract Ketamine is an ionic glutamic acid N-methyl-d-aspartate receptor (NMDAR) antagonist commonly used in clinical anesthesia, and its rapid and lasting antidepressant effect has stimulated great interest in psychology research. However, the molecular mechanisms...
by SmartTots | Sep 1, 2023 | Preclinical Articles, Research Articles
Abstract The FDA issued a warning that repeated and prolonged use of inhalational anaesthetics in children younger than 3 years may increase the risk of neurological damage. Robust clinical evidence supporting this warning is however lacking. A systematic review of...
