by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Objectives: Isoflurane (ISO) is widely used in the clinic and research. The authors aimed to explore whether Neobaicalein (Neob) could protect neonatal mice from ISO-induced cognitive damage. Method: The open field test, Morris water maze test, and tail...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Impaired cerebellar development of premature infants and the associated impairment of cerebellar functions in cognitive development could be crucial factors for neurodevelopmental disorders. Anesthetic- and hyperoxia-induced neurotoxicity of the immature...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Anesthetics such as sevoflurane are commonly administered to infants and children. However, the possible neurotoxicity caused by prolonged or repetitive exposure to it should be a concern. The neuroprotective effects of metformin are observed in many models...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Propofol is neurotoxic to trigger neuronal pyroptosis and dexmedetomidine possesses the ability to suppress proptosis. This study expounded on the protective functions of dexmedetomidine on propofol-induced pyroptosis of primary hippocampal neurons via...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Introduction: The development and maintenance of neural circuits is highly sensitive to neural activity. General anesthetics have profound effects on neural activity and, as such, there is concern that these agents may alter cellular integrity and interfere...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Exposure to commonly used anesthetics leads to neurotoxic effects in animal models-ranging from cell death to learning and memory deficits. These neurotoxic effects invoke a variety of molecular pathways, exerting either immediate or long-term effects at the...
