In 2016, the US Food and Drug Administration issued a Drug Safety Warning regarding general anesthesia and its use during pregnancy. In particular, the safety announcement required medication labels to describe the studies in young animals and pregnant animals that demonstrated an exposure to general anesthesia for more than 3 hours may cause effects on the developing brain and may have long-term effects on learning and behavior. In other words, women who require surgery during pregnancy must be advised of the potential risk to the newborn in regard to its effect on learning and behavior. In response to this warning, the American College of Obstetricians and Gynecologists in conjunction with the American Society of Anesthesiologists updated the Committee Opinion on Nonobstetric Surgery During Pregnancy to include the statement, “There is no evidence that in utero human exposure to anesthetic or sedative drugs has any effect on the developing fetal brain.” This lack of studies in humans changes with the publication, “Prenatal Exposure to General Anesthesia and Childhood Behavioral Deficit,” in this issue of Anesthesia & Analgesia. Using a database in which pregnant women and their offspring were followed and tested after anesthetic exposure, a possible effect of general anesthesia on the child was detected. The use of general anesthesia during pregnancy had a negative effect on the child’s behavior when assessed at 10 years of age.