The editors highlight eight “intriguing” papers on age-dependent anesthetic effects in the developing brain, their mechanisms, and clinical applications. Important topics include 1) mechanisms underlying anesthesia-induced neurotoxicity and cognitive impairments in neonates; 2) the present state of clinical and basic research, and the challenges, in transferring information from animal investigations to clinical treatment; 3) clinical research components on the effects of prenatal anesthesia in neonates; 4) the impact of anesthesia monitoring devices in the perioperative period; and 5) applicable neuroprotective techniques and prospective therapeutic interventions.  

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Yang Yu, Yonghao Yu, Yiying Zhang, & Huihui Miao.
Frontiers in Neurology August 2023