Two major literature review articles and three editorials by experts on the effects of anesthesia in the developing brain were published in a recent issue of Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists (ASA), to address a warning issued by the U.S. Food and Drug Administration (FDA) in December 2016 noting that repeated or lengthy use of general anesthesia and sedation drugs may affect the development of children’s brains. The warning was based primarily on results from studies of laboratory animals that may not translate to humans.
- Cyclophilin D Contributes to Anesthesia Neurotoxicity in the Developing Brain
- Evaluation of the Toxicity of Sugammadex in Zebrafish Larvae
- Potential Neurodevelopmental Effects of Pediatric Intensive Care Sedation and Analgesia: Repetitive Benzodiazepine and Opioid Exposure Alters Expression of Glial and Synaptic Proteins in Juvenile Rats
- Sevoflurane inhibits neuronal migration and axon growth in the developing mouse cerebral cortex
- Iron overload contributes to general anaesthesia-induced neurotoxicity and cognitive deficits