Two major literature review articles and three editorials by experts on the effects of anesthesia in the developing brain were published in a recent issue of Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists (ASA), to address a warning issued by the U.S. Food and Drug Administration (FDA) in December 2016 noting that repeated or lengthy use of general anesthesia and sedation drugs may affect the development of children’s brains. The warning was based primarily on results from studies of laboratory animals that may not translate to humans.
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- Sevoflurane diminishes neurogenesis and promotes ferroptosis in embryonic prefrontal cortex via inhibiting nuclear factor-erythroid 2-related factor 2 expression.
- Neonatal Anesthesia and Oxidative Stress.
- LncRNA SNHG12 ameliorates bupivacaine-induced neurotoxicity by sponging miR-497-5p to upregulate NLRX1.
- Downregulation of HOTAIR reduces neuronal pyroptosis by targeting miR-455-3p/NLRP1 axis in propofol-treated neurons in vitro.
- MiRNA-384-5p targets GABRB1 to regulate ketamine-Induced Neurotoxicity in Neurons.