Two major literature review articles and three editorials by experts on the effects of anesthesia in the developing brain were published in a recent issue of Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists (ASA), to address a warning issued by the U.S. Food and Drug Administration (FDA) in December 2016 noting that repeated or lengthy use of general anesthesia and sedation drugs may affect the development of children’s brains. The warning was based primarily on results from studies of laboratory animals that may not translate to humans.
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- Neonatal general anesthesia causes lasting alterations in excitatory and inhibitory synaptic transmission in the ventrobasal thalamus of adolescent female rats
- Mild hypothermia ameliorates anesthesia toxicity in the neonatal macaque brain
- Using animal models to evaluate the functional consequences of anesthesia during early neurodevelopment
- microRNA‐124 attenuates isoflurane‐induced neurological deficits in neonatal rats via binding to EGR1
- Hemin treatment protects neonatal rats from sevoflurane-induced neurotoxicity via the phosphoinositide 3-kinase/Akt pathway