Two major literature review articles and three editorials by experts on the effects of anesthesia in the developing brain were published in a recent issue of Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists (ASA), to address a warning issued by the U.S. Food and Drug Administration (FDA) in December 2016 noting that repeated or lengthy use of general anesthesia and sedation drugs may affect the development of children’s brains. The warning was based primarily on results from studies of laboratory animals that may not translate to humans.
Recent Posts
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- Embryonic exposure to fentanyl induces behavioral changes and neurotoxicity in zebrafish larvae.
- Sevoflurane induces neurotoxic effects on developing neurons through the WNK1/NKCC1/Ca2+ /Drp-1 signalling pathway.
- Single-nucleus atlas of sevoflurane-induced hippocampal cell-type- and sex-specific effects during development in mice.
- Ketamine impairs growth cone and synaptogenesis in human GABAergic projection neurons via GSK-3β and HDAC6 signaling.