In their recent Editorial, Drs. Vutskits and Culley discuss the General Anesthesia or Awake-regional Anesthesia in Infancy (GAS), Pediatric Anesthesia Neurodevelopment Assessment (PANDA), and Mayo Anesthesia Safety in Kids (MASK) studies.1 These studies are similar in that they all prospectively tested children exposed to a single anesthetic at a young age using comprehensive batteries of neurodevelopmental assessments. While this Editorial interprets these studies as showing “No Evidence of Clinical Anesthetic Neurotoxicity!” with an emphatic exclamation point, we respectfully disagree for two reasons.

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