Researchers at the Mayo Clinic in collaboration with the National Center for Toxicological Research (NCTR) are conducting a population-based study of long-term cognitive development in a large cohort of Rochester, MN children. The study compares performance of children with no anesthetic exposure to those with single or multiple exposures prior to age three years on an extensive battery of neurocognitive tests including the operant test battery (OTB). Researchers at NCTR and Arkansas Children’s Hospital are using the OTB to evaluate cognitive performance in both children and non-human primates.
- Ketamine-induced neurotoxicity in neurodevelopment: A synopsis of main pathways based on recent in vivo experimental findings.
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- RIPK1/RIPK3-Mediated Necroptosis is Involved in Sevoflurane-Induced Neonatal Neurotoxicity in the Rat Hippocampus.
- lncRNA Xist regulates sevoflurane-induced social and emotional impairment by modulating miR-98-5p/EDEM1 signaling axis in neonatal mice.
- Hypermethylation of EFEMP1 in the Hippocampus May Be Related to the Deficit in Spatial Memory of Rat Neonates Triggered by Repeated Administration of Propofol.