Researchers at the Mayo Clinic in collaboration with the National Center for Toxicological Research (NCTR) are conducting a population-based study of long-term cognitive development in a large cohort of Rochester, MN children. The study compares performance of children with no anesthetic exposure to those with single or multiple exposures prior to age three years on an extensive battery of neurocognitive tests including the operant test battery (OTB). Researchers at NCTR and Arkansas Children’s Hospital are using the OTB to evaluate cognitive performance in both children and non-human primates.
- Behavioural impairments after exposure of neonatal mice to propofol are accompanied by reductions in neuronal activity in cortical circuitry.
- Protective Effect of GM1 Attenuates Hippocampus and Cortex Apoptosis After Ketamine Exposure in Neonatal Rat via PI3K/AKT/GSK3β Pathway.
- Singular and short-term anesthesia exposure in the developing brain induces persistent neuronal changes consistent with chronic neurodegenerative disease.
- Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway.
- Effect of dexmedetomidine on sevoflurane-induced neurodegeneration in neonatal rats.