In 1981, a startling article was published in Anesthesia& Analgesia: “Exposure to Halothane and Enflurane Affects Learning Function of Murine Progeny.” The study found that adolescent mice that had been exposed in utero to halothane or enflurane anesthesia had markedly impaired maze learning compared with unexposed controls. Decades before the discovery of epigenetics, the article even showed that, in some cases, impairments were also found in the next generation. The authors proposed further research to explore the relevance of their findings to anesthesia in humans. The article was, however, largely ignored and the authors’ proposal not pursued.
- Z-DNA/RNA Binding Protein 1 Senses Mitochondrial DNA to Induce Receptor-Interacting Protein Kinase-3/Mixed Lineage Kinase Domain-Like-Driven Necroptosis in Developmental Sevoflurane Neurotoxicity.
- Embryonic exposure to fentanyl induces behavioral changes and neurotoxicity in zebrafish larvae.
- Sevoflurane induces neurotoxic effects on developing neurons through the WNK1/NKCC1/Ca2+ /Drp-1 signalling pathway.
- Single-nucleus atlas of sevoflurane-induced hippocampal cell-type- and sex-specific effects during development in mice.
- Ketamine impairs growth cone and synaptogenesis in human GABAergic projection neurons via GSK-3β and HDAC6 signaling.