In 1981, a startling article was published in Anesthesia& Analgesia: “Exposure to Halothane and Enflurane Affects Learning Function of Murine Progeny.” The study found that adolescent mice that had been exposed in utero to halothane or enflurane anesthesia had markedly impaired maze learning compared with unexposed controls. Decades before the discovery of epigenetics, the article even showed that, in some cases, impairments were also found in the next generation. The authors proposed further research to explore the relevance of their findings to anesthesia in humans. The article was, however, largely ignored and the authors’ proposal not pursued.
- Neuroprotective Effects of Dexmedetomidine on the Ketamine-Induced Disruption of the Proliferation and Differentiation of Developing Neural Stem Cells in the Subventricular Zone.
- NPAS4 suppresses propofol-induced neurotoxicity by inhibiting autophagy in hippocampal neuronal cells.
- Effect of operative trauma and multiple propofol anesthesia on neurodevelopment and cognitive function in developmental rats.
- FOXO3 Regulates Sevoflurane-Induced Neural Stem Cell Differentiation in Fetal Rats
- Inhibiting PDE7A Enhances the Protective Effects of Neural Stem Cells on Neurodegeneration and Memory Deficits in Sevoflurane-Exposed Mice.