More than one million children under the age of five undergo surgery annually in the United States. The most common procedures are myringotomy tubes, tonsillectomy/adenoidectomy, hernia repairs, and circumcisions. Recently, the issue of anesthesia-related neurotoxicity has been in the media limelight, and parents are appropriately fearful about the effects of general anesthesia on their child’s brain development.
- Anesthetic Neurotoxicity
- Further Study Needed of the Impact of Early-Life Surgery With Associated General Anesthesia on the Risk of Attention Deficit Hyperactivity Disorder.
- Procedural Sedation Outside the Operating Room and Potential Neurotoxicity: Analysis of an At-Risk Pediatric Population.
- Role of sedative-hypnotic agents in neurodegeneration: Effects of midazolam and thiopental on apoptosis and oxidative stress expression in neonatal and adult rat brains.
- Blockade of the NLRP3/caspase-1 axis attenuates ketamine-induced hippocampus pyroptosis and cognitive impairment in neonatal rats.