Millions of babies and children undergo anaesthesia every year. Preclinical evidence shows that all common anaesthetic drugs are associated with neuro-apoptosis and neurodevelopmental deficits in immature rodent models. Xenon, a low-potency anaesthetic gas, renowned for producing cardiostable anaesthesia and with neuroprotective properties in multiple pathologies, was recently used to reduce sevoflurane requirements of babies and young children undergoing cardiac catheterisation. Preclinical studies have shown the addition of xenon reduced neuroapoptosis induced by 0.7% isoflurane in vivo and in vitro.
- Propofol and Sevoflurane Anesthesia in Early Childhood Do Not Influence Seizure Threshold in Adult Rats.
- Sevoflurane Exposure in the Developing Brain Induces Hyperactivity, Anxiety-Free, and Enhancement of Memory Consolidation in Mice.
- Fentanyl induces autism-like behaviours in mice by hypermethylation of the glutamate receptor gene Grin2b.
- Multiple exposures to sevoflurane across postnatal development may cause cognitive deficits in older age.
- Mitochondria-Related Ferroptosis Drives Cognitive Deficits in Neonatal Mice Following Sevoflurane Administration.