by SmartTots | Jun 25, 2020 | Research Articles
Abstract In March 2019, SmartTots, a public-private partnership between the US Food and Drug Administration and the International Anesthesia Research Society, hosted a meeting attended by research experts, anaesthesia journal editors, and government agency...
by SmartTots | May 13, 2020 | Research Articles
Abstract Perioperative risk of morbidity and mortality for neonates is significantly higher than that for older children and adults. At particular risk are neonates born prematurely, neonates with major or severe congenital heart disease, and neonates with pulmonary...
by SmartTots | May 13, 2020 | Research Articles
Abstract Background 17AAG has been extensively studied for its antitumor effects that protect cells from lethal stress by maintaining protein stability. The role of 17AAG in sevoflurane-induced neuronal injury has never been studied. We aim to investigate the effect...
by SmartTots | May 13, 2020 | Research Articles
Abstract Purpose In this study, we investigated the effects of different concentration of propofol on cell viability of hippocampal neurons and explored the possible mechanism. Patients and methods Primary hippocampal neurons were cultured in vitro and treated with...
by SmartTots | May 13, 2020 | Research Articles
Abstract Recent years, the number of neonatal patients receiving surgery under general anesthesia is increasing. Previous studies have indicated that ketamine can disturb the proliferation and differentiation of developing neural stem cells (NSCs). Therefore, the safe...
by SmartTots | May 13, 2020 | Research Articles
Abstract Prenatal propofol exposure induced neurotoxicity in the developing brains and led to persistent learning deficits in the offspring. Our goal was to use zebrafish to explore whether the decline in learning and memory was correlated with inhibition of neuronal...
