by SmartTots | Jul 15, 2019 | Research Articles
Abstract Importance Limited studies have reported associations between anesthesia and neurocognitive and neuroimaging outcomes, particularly in pediatric patients who undergo multiple exposures to anesthesia as part of chronic disease management. Objective To...
by SmartTots | Jul 15, 2019 | Research Articles
Abstract Two decades ago, the possibility that anesthetics could harm the developing brain was identified in rodents. This work has been replicated in multiple species, including subhuman primates, raising serious concern in the anesthesia community and leading to a...
by SmartTots | Jul 15, 2019 | Research Articles
Abstract Propofol is a commonly used general anesthetic in patient care. Recent studies have shown that propofol has neurological side effects especially in young children, which raises a concern regarding the safety of its use. We explored the effects of the...
by SmartTots | Jul 15, 2019 | Research Articles
Abstract Volatile anesthetics are widely used in human medicine and generally considered to be safe in healthy individuals. In recent years, the safety of volatile anesthesia in pediatric patients has been questioned following reports of anesthetic induced...
by SmartTots | Jul 15, 2019 | Research Articles
Abstract Prolonged or repeated exposure to ketamine, a common anesthetic in pediatrics, has been shown to induce neurotoxicity and long-term neurocognitive deficits in the developing brain. Therefore, identification of potential therapeutic targets for preventing or...
by SmartTots | Jul 15, 2019 | Research Articles
Abstract Background Exposure to anesthetics during early life may impair cognitive functions. However, the underlying mechanisms remain largely unknown. We set out to determine effects of sevoflurane anesthesia on folate metabolism and myelination in young non-human...
