by SmartTots | May 4, 2019 | Research Articles
Abstract Sevoflurane is one of the most commonly used volatile anaesthetics in general anaesthesia in children. Sevoflurane anaesthesia (2–2.5% for 4–6 h) can cause neuronal apoptosis and long-term learning and memory impairment in multiple brain regions of neonatal...
by SmartTots | May 4, 2019 | Research Articles
Abstract Recent evidence has shown that general anaesthesia can cause long-term neurotoxicity and cognitive dysfunction. Ketamine is commonly used in paediatric anaesthesia and antidepressant therapy. Increasing data indicate that ketamine can induce neuronal...
by SmartTots | May 4, 2019 | Research Articles
Abstract Background The factors determining peak susceptibility of the developing brain to anaesthetics are unclear. It is unknown why postnatal day 7 (P7) male rats are more vulnerable to anaesthesia-induced memory deficits than littermate females. Given the...
by SmartTots | May 4, 2019 | Research Articles
Abstract Background Propofol is a commonly used general anesthetic for the induction and maintenance of anesthesia and critical care sedation in children, which may add risk to poor neurodevelopmental outcome. We aimed to evaluate the effect of propofol toward primary...
by SmartTots | May 4, 2019 | Research Articles
Abstract Initially used as an analgesic and anesthetic, ketamine has unfortunately been abused as a popular recreational party drug due to its psychotropic effects. Over the last decade, ketamine has also emerged as an effective rapid-onset anti-depressant. The...
by SmartTots | May 4, 2019 | Research Articles
Abstract Isoflurane is commonly used in pediatric population, but its mechanism of action in cognition is unclear. Aquaporin 4 (AQP4) regulates water content in blood, brain, and cerebrospinal fluid. Various studies have provided evidence for the role of AQP4 in...
