by SmartTots | Feb 14, 2026 | Preclinical Articles, Research Articles
This editorial responds to Armijo, et al citing that it is, at best, very difficult to compare functional outcome measures used in laboratory experiments with those applied to human studies. However, the editorial authors acknowledge that these recent laboratory...
by SmartTots | Feb 14, 2026 | Preclinical Articles, Research Articles
Abstract Background: Sevoflurane impairs neurogenesis and cognitive function in the developing brain; however, the underlying mechanisms remain unclear. This study aimed to investigate the role of fatty acid β-oxidation (FAO) in neural stem/progenitor cells (NSPCs) as...
by SmartTots | Feb 13, 2026 | Preclinical Articles, Research Articles
Abstract Background: General anaesthetics are essential for paediatric surgery but have been associated with neuronal injury and long-term cognitive deficits, thereby raising concerns over neurodevelopmental safety. However, the molecular mechanisms underlying...
by SmartTots | Feb 13, 2026 | Preclinical Articles, Research Articles
Abstract Background: Anesthetic exposure during childhood is significantly associated with impairment of neurodevelopmental outcomes; however, the causal relationship and detailed mechanism of developmental anesthetic neurotoxicity remain unclear. Gut microbiota...
by SmartTots | Feb 13, 2026 | Preclinical Articles, Research Articles
Abstract As a widely used pediatric anesthetic, sevoflurane presents a paradoxical neurodevelopmental risk during vulnerable brain maturation periods. This review synthesizes emerging evidence on sevoflurane-induced developmental neurotoxicity, with a focus on...
by SmartTots | Feb 13, 2026 | Preclinical Articles, Research Articles
Abstract Background: Sevoflurane induces neuronal dysfunction and cognitive impairment. However, the underlying mechanism remains largely to be determined. Tau, cyclophilin D, and dendritic spine contribute to cognitive function. But whether changes in dendritic...
