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Multiple General Anesthesia in Children: A Systematic Review of Its Effect on Neurodevelopment.

by SmartTots | Jun 28, 2023 | Clinical Articles, Research Articles

Abstract The effect of multiple general anesthesia (mGA) procedures administered in early life is a critical theme and has led the Food and Drug Administration (FDA) to issue an alert. This systematic review seeks to explore the potential effects on neurodevelopment...

Early exposure to general anaesthesia and increasing trends in developmental behavioural impairments: is there a link?

by SmartTots | Jun 28, 2023 | Clinical Articles, Research Articles

Abstract Over the past two decades there has been an increase in reports of attention deficit-hyperactivity disorder and perhaps autism spectrum disorder that appear to coincide with a substantial number of general anaesthesia interventions during early stages of...

Controversies in anesthesia-induced developmental neurotoxicity.

by SmartTots | Jun 28, 2023 | Clinical Articles, Research Articles

Abstract Advances in the field of pediatric anesthesiology have enabled the performance of complex and life-saving procedures with minimal patient discomfort. However, preclinical studies over the past two decades have been reporting substantial neurotoxic potential...
October 13 – 17 SmartTots in San Francisco!

October 13 – 17 SmartTots in San Francisco!

by SmartTots | May 19, 2023 | Events

Effect of sevoflurane anesthesia to neonatal rat hippocampus by RNA-seq.

by SmartTots | May 1, 2023 | Preclinical Articles, Research Articles

Abstract Background: Sevoflurane is an inhalational anesthetic for the induction and maintenance of general anesthesia in pediatric surgery. However, few studies have paid attention to the multiple organ toxicity and the mechanism behind it. Methods: Inhalation...
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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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