by SmartTots | Jul 7, 2022 | Research Articles
Abstract Objective: Sevoflurane is a common anesthetic and is widely used in pediatric clinical surgery to induce and maintain anesthesia through inhalation. Increasing studies have revealed that sevoflurane has neurotoxic effects on neurons, apoptosis, and memory...
by SmartTots | Jul 7, 2022 | Research Articles
Abstract Background: General anaesthesia in the neonatal period has detrimental effects on the developing mammalian brain. The impact of underlying inflammation on anaesthesia-induced developmental neurotoxicity remains largely unknown. Methods: Postnatal day 7 (PND7)...
by SmartTots | Jul 7, 2022 | Research Articles
“A substitute shines brightly as a king until a king be by” Portia, Act 5, Scene 1, The Merchant of Venice, William Shakespeare. Nonhuman primates (NHPs) have been important surrogates for modeling human diseases. In the field of perioperative medicine, preclinical...
by SmartTots | Jul 7, 2022 | Research Articles
Abstract Importance Clinical studies of neurodevelopmental outcomes after anesthetic exposure have evaluated a range of outcomes with mixed results. Objective To examine via meta-analyses the associations between exposure to general anesthesia and domain-specific...
by SmartTots | Jul 7, 2022 | Research Articles
Abstract Objective: To evaluate possible negative long-term effects of neonatal exposure to pain, opioids and anesthetics in children and adolescents. Study design: We studied five unique groups of children recruited from well-documented neonatal cohorts with a...
