by SmartTots | Nov 3, 2023 | Clinical Articles, Research Articles
Despite decades of research, the question of developmental anesthetic neurotoxicity remains unsettled and continues to divide the medical community and beyond. Additionally, it continues to remain unknown if there is a clinically relevant biologic gradient of...
by SmartTots | Nov 3, 2023 | Clinical Articles, Research Articles
Abstract Background: Children undergoing complex cardiac surgery are exposed to substantial cumulative doses of sedative medications and volatile anesthetics and are more frequently anesthetized with ketamine, compared with healthy children. This study hypothesized...
by SmartTots | Sep 1, 2023 | Preclinical Articles, Research Articles
The editors highlight eight “intriguing” papers on age-dependent anesthetic effects in the developing brain, their mechanisms, and clinical applications. Important topics include 1) mechanisms underlying anesthesia-induced neurotoxicity and cognitive impairments in...
by SmartTots | Sep 1, 2023 | Preclinical Articles, Research Articles
Abstract With advances in pediatric and obstetric surgery, pediatric patients are subject to complex procedures under general anesthesia. The effects of anesthetic exposure on the developing brain may be confounded by several factors including pre-existing disorders...
by SmartTots | Sep 1, 2023 | Preclinical Articles, Research Articles
Abstract Background: The volatile anaesthetic sevoflurane induces time (single or multiple exposures)-dependent effects on tau phosphorylation and cognitive function in young mice. The underlying mechanism for this remains largely undetermined. Methods: Mice received...
