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Dexmedetomidine Attenuates Neurotoxicity Induced by Prenatal Propofol Exposure.

by SmartTots | Apr 4, 2015 | Research Articles

J Neurosurg Anesthesiol, April 2015. Li J, Xiong M, Nadavaluru PR, Zuo W, Ye JH, Eloy JD, Bekker A.   Abstract  BACKGROUND:  Anesthetic agents (eg, isoflurane, propofol) may cause neurodegeneration in the developing brains and impair animals’ learning ability....

Neurodevelopmental implications of the general anesthesia in neonate and infants

by SmartTots | Apr 3, 2015 | Research Articles

Exp Neurol, April 2015. Lee JH, Zhang J, Wei L, Yu SP   Abstract Each year, about six million children, including 1.5 million infants, in the United States undergo surgery with general anesthesia, often requiring repeated exposures. However, a crucial question remains...

Isoflurane induced cognitive impairment in aged rats through hippocampal calcineurin/NFAT signaling

by SmartTots | Apr 3, 2015 | Research Articles

Biochem Biophys Res Commun, April 2015. Ni C, Li Z, Qian M, Zhou Y, Wang J, Guo X.   Abstract Calcineurin (CaN) over-activation constrains synaptic plasticity and memory formation. Upon CaN activation, NFAT imports into the nucleus and guides its downstream genes,...

Oregon Health & Science University: Ansgar Brambrink, MD, PhD

by SmartTots | Apr 2, 2015 | Research Articles

Project: Long-Term Outcome of Single vs. Triple Anesthesia Exposure of Infant Monkeys Dr. Brambrink proposes using their newly established infant non-human primate (NHP) model to simulate the human condition of general anesthesia in a highly controlled environment...

Developmental stage-dependent impact of midazolam on calbindin, calretinin and parvalbumin expression in the immature rat medial prefrontal cortex during the brain growth spurt.

by SmartTots | Apr 2, 2015 | Research Articles

Int J Dev Neurosci, April 2015.  Osterop SF, Virtanen MA, Loepke JR, Joseph B, Loepke AW, Vutskits L   Abstract  BACKGROUND: Human epidemiological data suggest a link between anesthesia exposure in early postnatal life and subsequent lasting neurocognitive...
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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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