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Clinical Research Into Anesthetic Neurotoxicity: Does Anesthesia Cause Neurological Abnormalities in Humans?

by SmartTots | Oct 15, 2014 | Research Articles

Journal of Neurosurgical Anesthesiology, October 2014. Lei SY, Hache M, Loepke AW Summary General anesthetics mitigate distress and exaggerated hemodynamic responses to pain and stressful stimulation, allowing surgery and diagnostic procedures to be performed...

Isoflurane Impairs the Capacity of Astrocytes to Support Neuronal Development in a Mouse Dissociated Coculture Model

by SmartTots | Oct 14, 2014 | Research Articles

Journal of Neurosurgical Anesthesiology, October 2014. Ryu YK, Khan S, Sarah C, Mintz C. Abstract Background: There is growing concern that pediatric exposure to anesthetic agents may cause long-lasting deficits in learning by impairing brain development. Most studies...

Ketamine Affects the Neurogenesis of Rat Fetal Neural Stem Progenitor Cells via the PI3K/Akt-p27 Signaling Pathway.

by SmartTots | Oct 12, 2014 | Research Articles

Birth defects research. Part B, Developmental and reproductive toxicology, October 2014. Dong C, Rovnaghi CR, Anand KJ. Abstract Ketamine is widely used as an anesthetic, analgesic, or sedative in pediatric patients. We reported that ketamine alters the normal...

Review: effects of anesthetics on brain circuit formation.

by SmartTots | Oct 11, 2014 | Research Articles

Journal of Neurosurgical Anesthesiology, October 2014. Wagner M, Ryu YK, Smith SC, Mintz CD Abstract The results of several retrospective clinical studies suggest that exposure to anesthetic agents early in life is correlated with subsequent learning and behavioral...

General Anesthesia Causes Long-term Impairment of Mitochondrial Morphogenesis and Synaptic Transmission in Developing Rat Brain

by SmartTots | Oct 3, 2014 | Research Articles

Sanchez, Victoria B.S.; Feinstein, Shawn D. B.A.; Lunardi, Nadia M.D.; Joksovic, Pavle M. M.D.; Boscolo, Annalisa M.D.; Todorovic, Slobodan M. M.D., Ph.D.; Jevtovic-Todorovic, Vesna M.D., Ph.D., M.B.A. Anesthesiology. 2011 Sept 8. [Epub ahead of print] Abstract...
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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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