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Anesthesia in Children: Perspectives From Nonsurgical Pediatric Specialists

by SmartTots | Oct 1, 2014 | Research Articles

Journal of Neurosurgical Anesthesiology, October 2014. Monteleone M, Khandji A, Cappell J, Lai WW, Biagas K, Schleien C. Abstract The Pediatric Anesthesia NeuroDevelopment Assessment (PANDA) study investigates the potential neurotoxicity of anesthetics in the...

Sevoflurane induces tau phosphorylation and glycogen synthase kinase 3β activation in young mice

by SmartTots | Sep 22, 2014 | Research Articles

Anesthesiology, September 2014. Tao G, Zhang J, Zhang L, Dong Y, Yu B, Crosby G, Culley DJ, Zhang Y, Xie Z Abstract BACKGROUND: Children with multiple exposures to anesthesia and surgery may have an increased risk of developing cognitive impairment. Sevoflurane is a...

Role of miR-34c in ketamine-induced neurotoxicity in neonatal mice hippocampus

by SmartTots | Sep 5, 2014 | Research Articles

Cell Biol Int., July 23, 2014. Zhang Y, Tian J, Chen S, Zhang X, Cao SE Abstract Ketamine is a commonly used pediatric anesthetic, but it might affect development, or even induce neurotoxicity in the neonatal brain. We have used an in vivo neonatal mouse model to...

Effects of anesthesia on the developing brain: can the underlying disease be ignored?

by SmartTots | Sep 5, 2014 | Research Articles

Letter to the Editor   Effects of anesthesia on the developing brain: can the underlying disease be ignored?  SIR—Very few issues (if any) within pediatric anesthesia have created so much concern and emotional gravity than the possibility that general anesthetics...

Effects of anesthesia and surgery on the developing brain: problem solved?

by SmartTots | Sep 5, 2014 | Research Articles

Letter to the Editor   Effects of anesthesia and surgery on the developing brain: problem solved? We read with interest the recent review by Dr. Hansen of anesthetic neurotoxicity (1).  Another paper from his group (2) describes the analysis of educational...
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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

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SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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