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Anesthetic Related Neurotoxicity in Young Children: An Update

by SmartTots | Oct 15, 2012 | Research Articles

American Society of Anesthesiologists’ Anesthesiology 2012 Monday, Oct 15, 2012; 11:30 AM – 1:00 PM Location: 206 Session Track: Pediatric Anesthesia (PD) This panel will provide an update and overview of the evidence suggesting a relationship between anesthetic...

SmartTots: A Public-Private Partnership Between the United States Food and Drug Administration (FDA) and the International Anesthesia Research Society (IARS)

by SmartTots | Oct 13, 2012 | Research Articles

Ramsay JG, Roizen M, Davidson A Paediatr Anaesth. 2012 Oct;22(10):969-72. Summary A history of the public–private partnership ‘SmartTots’ between the IARS and FDA is presented. In order to raise money for research to better understand the relationship between sedative...

Experts Work Towards Developing Consensus Regarding Anesthetic Safety in Children

by SmartTots | Oct 8, 2012 | News

Over the last decade, studies in rodents and non-human primates have found that exposure to anesthetic agents during sensitive periods of brain development results in widespread neuronal apoptosis and functional deficits later in life. Recent population-based birth...

Isoflurane-induced apoptosis of oligodendrocytes in the neonatal primate brain

by SmartTots | Oct 2, 2012 | Research Articles

Ann Neurol. 2012 Oct;72(4):525-35. Brambrink AM, Back SA, Riddle A, Gong X, Moravec MD, Dissen GA, Creeley CE, Dikranian KT, Olney JW. Abstract OBJECTIVE: Previously we reported that exposure of 6-day-old (P6) rhesus macaques to isoflurane for 5 hours triggers a...

Propofol at Clinically Relevant Concentrations Increases Neuronal Differentiation But Is Not Toxic to Hippocampal Neural Precursor Cells In Vitro

by SmartTots | Sep 20, 2012 | Research Articles

Sall JW, Stratmann G, Leong J, Woodward E, Bickler PE Anesthesiology. 2012 Sep 20. [Epub ahead of print] Abstract BACKGROUND:: Propofol in the early postnatal period has been shown to cause brain cell death. One proposed mechanism for cognitive dysfunction after...
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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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