by SmartTots | Jul 11, 2020 | Research Articles
Abstract Background: Preclinical studies suggest that exposures of infant animals to general anesthetics cause acute neurotoxicity and affect their neurobehavioral development representing a potential risk to human infants undergoing anesthesia. Alternative or...
by SmartTots | Jul 11, 2020 | Research Articles
Abstract Many studies have shown that prolonged or repeated use of general anesthesia early in life can cause an increase in neurodegeneration and lasting changes in behavior. While short periods of general anesthesia appear to be safe, there is a concern about the...
by SmartTots | Jul 11, 2020 | Research Articles
Abstract Objective Early exposure to general anesthesia in children might be a potentially high-risk factor for learning and behavioral disorders. The mechanism of neurotoxicity induced by general anesthesia was not defined. miR-496 could regulate cerebral injury,...
by SmartTots | Jul 11, 2020 | Research Articles
Abstract Background Anesthesia in pregnant rodents causes neurotoxicity in fetal and offspring rodents. However, the underlying mechanisms and targeted treatments remain largely to be determined. Isoflurane and propofol are among commonly used anesthetics. Thus, we...
by SmartTots | Jul 11, 2020 | Research Articles
Abstract Sevoflurane may exert neurotoxic effects on the developing brain. Coenzyme Q10 (CoQ10) has been reported to reduce sevoflurane anesthesia-induced cognitive deficiency in 6-day-old mice. However, its specific mechanisms remain unknown. Apolipoprotein E (ApoE)...
