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Distinct, sex-dependent miRNA signatures in piglet hippocampus induced by a clinically relevant isoflurane exposure: a pilot study.

by SmartTots | Mar 13, 2020 | Research Articles

Abstract Purpose To evaluate the effects of sex on miRNA expression in the hippocampus after isoflurane anesthesia in a neonatal piglet model. Methods Six male and 6 female piglets, aged 3–5 days, were anesthetized with 2% isoflurane in room air for 3 h. Full...

Vitexin improves neuron apoptosis and memory impairment induced by isoflurane via regulation of miR-409 expression.

by SmartTots | Mar 13, 2020 | Research Articles

Abstract Background: Anesthetics, such as isoflurane, sevoflurane, ketamine, and desflurane, are commonly used in clinics. Specifically, isoflurane is one of the most commonly used inhalational anesthetics, which can be used in surgery patients of all ages, including...

MicroRNA-582-5p reduces propofol-induced apoptosis in developing neurons by targeting ROCK1.

by SmartTots | Mar 13, 2020 | Research Articles

Abstract Background: Propofol is an intravenous drug commonly used in anesthesia procedures and intensive care in children. However, it also has neurotoxic effects on children. MicroRNA plays an important role in neurological diseases and neurotoxicity. Methods: In...

General Anesthetic-Induced Neurotoxicity in the Immature Brain: Reevaluating the Confounding Factors in the Preclinical Studies.

by SmartTots | Mar 13, 2020 | Research Articles

Abstract General anesthetic (GA) is used clinically to millions of young children each year to facilitate surgical procedures, relieve perioperative stress, and provide analgesia and amnesia. During recent years, there is a growing concern regarding a causal...

Paediatric Anaesthesia Neurotoxicity: Bring Back the Papoose Board?

by SmartTots | Mar 13, 2020 | Research Articles

Abstract Every day children of all ages are sedated or anaesthetized for dental treatment both in the hospital and more commonly now in the dental office. The use of physical restraint for a dental procedure in a child has largely been replaced or significantly...
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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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