by SmartTots | Nov 3, 2019 | Research Articles
Abstract Excessive exposure to commonly used anesthetic agents, such as ketamine, may induce permanent damage to immature human brains. In this work, we used a human embryonic stem cell (hESC)-derived neuron model to assess the expression and function of human...
by SmartTots | Nov 3, 2019 | Research Articles
Abstract Most clinically used general anesthetics have demonstrated neurotoxicity in animal studies, but the related mechanisms remain unknown. Previous studies suggest that anesthetics affect neuronal development through neuroinflammation, and significant effects of...
by SmartTots | Nov 3, 2019 | Research Articles
Abstract Background: Anesthesia-induced neurotoxicity may cause permanent dysfunctions in human brains. In this work, we used a cell-based in-vitro model to demonstrate that traditional Chinese medicine, Kami-Shoyo-San may protect ketamine-induced neuronal apoptosis...
by SmartTots | Nov 3, 2019 | Research Articles
Abstract A large number of preclinical studies have established that general anesthetics (GAs) may cause neurodevelopmental toxicity in rodents and nonhuman primates, which is followed by long-term cognitive deficits. The subiculum, the main output structure of...
by SmartTots | Nov 3, 2019 | Research Articles
Abstract The cation-chloride cotransporters Na+-K+-2Cl–1 (NKCC1) and K+-2Cl–2 (KCC2) critically regulate neuronal responses to gamma-aminobutyric acid (GABA). NKCC1 renders GABA excitatory in immature neurons while expression of KCC2 signals GABA...
