by SmartTots | Feb 19, 2019 | Research Articles
The Sixth PANDA Symposium was held on April 14th and 15th, 2018. The 2-day symposium program included the following sessions: (1) Report of the Outcomes Workshop, September 2017, (2) Lessons learned: neuroimaging studies and neurodevelopmental outcome research, (3)...
by SmartTots | Feb 15, 2019 | Research Articles
Summary Background In laboratory animals, exposure to most general anaesthetics leads to neurotoxicity manifested by neuronal cell death and abnormal behaviour and cognition. Some large human cohort studies have shown an association between general anaesthesia at a...
by SmartTots | Jan 4, 2019 | Research Articles
Abstract BACKGROUND AND OBJECTIVES: Developing brain is more vulnerable to environmental risk than is the developed brain. We evaluated the effects of repeated exposure to different concentrations of sevoflurane on the neonatal mouse hippocampus using stereological...
by SmartTots | Jan 4, 2019 | Research Articles
Abstract Despite the widespread use of general anesthesia, a growing body of research suggests that anesthesia exposure early in life may be associated with acute neurotoxicity and lasting behavioral changes. To better evaluate the risk posed by early life anesthesia...
by SmartTots | Jan 4, 2019 | Research Articles
Abstract BACKGROUND: Sex plays an important yet often underexplored role in neurodevelopment and neurotoxicity. While several studies report the importance of sex regarding anesthesia-induced neurotoxicity in neonatal mice, only few have focused on the late postnatal...
