by SmartTots | Mar 9, 2021 | Research Articles
Abstract The complexity of investigating a phenomenon where a direct cause-and-effect relationship may not be possible to establish cannot be overestimated. How can one with absolute certainty make a causal connection between an event in the distant past with the...
by SmartTots | Mar 7, 2021 | Research Articles
Abstract Background Non-human primates are commonly used in neuroimaging research for which general anaesthesia or sedation is typically required for data acquisition. In this analysis, the cumulative effects of exposure to ketamine, Telazol® (tiletamine and...
by SmartTots | Mar 7, 2021 | Research Articles
Abstract Anesthetics are deemed necessary for all major surgical procedures. However, they have also been found to exert neurotoxic effects when tested on various experimental models, but the underlying mechanisms remain unknown. Earlier studies have implicated...
by SmartTots | Mar 7, 2021 | Research Articles
Abstract Background Hesperidin (HPD) is a bioflavonoid found in citrus fruits. This study aimed to investigate the effects of HPD on cerebral morphology and cognitive behavior in sevoflurane anesthetized neonatal rats and the molecular mechanisms involved. Material...
by SmartTots | Mar 7, 2021 | Research Articles
Abstract Background Anesthetic sevoflurane induces tau phosphorylation and cognitive impairment in young mice. The underlying mechanism and the targeted interventions remain largely unexplored. We hypothesized that dexmedetomidine and clonidine attenuated...
