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The genetics of isoflurane-induced developmental neurotoxicity

by SmartTots | May 16, 2017 | Research Articles

Abstract Introduction Neurotoxicity induced by early developmental exposure to volatile anesthetics is a characteristic of organisms across a wide range of species, extending from the nematode C. elegans to mammals. Prevention of anesthetic-induced neurotoxicity (AIN)...

Neurogenesis and developmental anesthetic neurotoxicity

by SmartTots | May 16, 2017 | Research Articles

Abstract The mechanism by which anesthetics might act on the developing brain in order to cause long term deficits remains incompletely understood. The hippocampus has been identified as a structure that is likely to be involved, as rodent models show numerous...

Introduction to the special issue “Developmental neurotoxicity associated with pediatric general anesthesia: Preclinical findings”

by SmartTots | May 16, 2017 | Research Articles

General anesthesia has been in clinical use for over two centuries. Nevertheless, while the field has achieved significant mastery over its clinical applications and protocols which allow for efficient delivery and sophisticated monitoring of our patients, significant...

Anaesthetic considerations for surgery in newborns

by SmartTots | May 15, 2017 | Research Articles

Abstract Almost 30 years ago, the American Academy of Pediatrics Committee on Fetus and Newborn coauthored a policy statement strongly advocating for the use of anaesthesia in all neonates stating ‘local or systemic pharmacologic agents now available permit...

The Risk of Going Under: Research paints a complex picture of how surgery and anesthesia might harm the brain, particularly in the elderly

by SmartTots | May 15, 2017 | Research Articles

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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

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SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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